More arteriosclerosis in transplant patients
ARTERIOSCLEROSIS progresses about three times faster in kidney transplant patients who develop antibodies in response to the donor organ, a study shows.
Examination of renal allograft biopsies in 100 patients, half of whom developed donor-specific antibodies (DSA), has shed light on one of the mechanisms of antibody-mediated rejection, researchers say.
The French study found that between three and 12 months after transplant, arteriosclerosis in antibody-positive patients progressed at a rate threefold higher than that in antibody-negative patients.
And rapid progression was significantly associated with subclinical antibody-mediated rejection, glomerulitis and interstitial inflammation.
“Acceleration of arteriosclerosis was a totally unexpected finding, an important one since it broadens our thinking about what constitutes transplant rejection,” lead author Dr Gary Hill said in a statement issued by the American