Mouse model brings hope for glioma

Combining a tricyclic antidepressant with an anticoagulant may seem an odd approach to treating brain cancer, but it works in mouse models, report Swiss researchers.

Intrigued by the observation that people on tricyclic antidepressants (TCAs) have a lower incidence of brain cancer, the researchers tested the TCA imipramine on laboratory mice genetically engineered to be prone to glioblastomas.

They found