NSAID role in preventing metastasis found

Researchers from the Peter MacCallum Cancer Centre’s tumour angiogenesis research program have found a gene (PGDH) that is crucial in linking tumour growth factors to the prostaglandin pathway.

Growth factors secreted by tumours widen nearby lymphatic vessels, and it is known that NSAIDS such as aspirin can shut down the dilation process, the researchers said.

“With many clinical trials around the world currently investigating the ability of NSAIDS to target the prostaglandin pathway, the discovery of this link unlocks a range of potentially powerful new therapies to target this pathway in lymphatic vessels