NSAIDs double bleeding risk with anticoagulants

Patients being treated with anticoagulants for venous thromboembolism have significantly higher odds of clinically relevant bleeding if they also take aspirin or non-steroidal anti-inflammatory drugs, according to a large international study.

Taking NSAIDs upped the risk of bleeding by 80% compared with non-NSAID use, showed data from over 8200 patients on anticoagulants for deep vein thrombosis or pulmonary embolism.

NSAIDs had an even more dramatic effect on the risk of major bleeding, leading to a 2.4-fold