Obesity gene link gathers strength

IT IS well accepted that type 2 diabetes has a heritable component, but identifying the genes responsible has proved elusive.

Professor Lesley Campbell, director of diabetes services at St Vincent’s Hospital, Sydney, studies predisposing genetic variants.

She says one reason for the failure to identify ‘type 2 diabetes’ genes has been poor phenotyping, whereby controls without diabetes were included in studies and then went on to develop diabetes.

“So they didn’t find many genes… or they found genes that only explained a very small amount [of predisposition],

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