Older NSAIDs raise vascular risks
The analysis of 639 randomised controlled trials found high doses of older NSAIDs, such as diclofenac at 150mg daily, increased major vascular events by about a third, in line with coxibs.
Ibuprofen also significantly increased major coronary events but not major vascular events.
Compared to placebo, of 1000 patients allocated to a coxib or diclofenac for a year, three more would have major vascular events, one of which would be fatal.
In high-risk patients, about seven or eight more would have a major vascular event, of which two would be