Options for blood glucose control

Diabetes is a progressive disease, and the combination of metformin and a sulfonylurea (or another form of dual therapy) is unlikely to control blood glucose in the long term.1 However, there is a lack of high-quality clinical trials comparing the effectiveness of the addition of different glucose lowering drugs, and their impact upon diabetic-related mortality and morbidity, in people receiving dual therapy.2,3

When metformin and a sulfonylurea no longer provide adequate blood glucose control, insulin therapy is preferred to adding a third non