Possible mechanism for white matter degeneration in Alzheimer’s

An Australian-led study has found a possible explanation for why white matter changes lead to Alzheimer’s disease.

The study led by Dr Lyndsey Collins-Praino from the University of Adelaide investigated the levels of soluble amyloid-beta in the white matter of 12 AD patients and 10 controls.

They found AD samples had higher white matter levels of soluble Aβ-42 and Aβ-40 compared with controls, consistent with the hypothesis that white matter degeneration could be caused by the toxicity of Aβ peptides.