PPI use linked to chronic kidney damage even without acute disease

Renal damage from prolonged use of proton-pump inhibitors (PPIs) can be silent and deadly, research shows.

The evaluation of US veterans’ databases of outcomes for 125,000 patients, who were new users of PPIs, shows that more than half of those who develop chronic kidney damage after five years do not experience acute kidney injury first

Comparing the PPI cohort with 18,000 new users of H2 blockers, the researchers found the PPI users have a significantly higher risk of eGFR <60ml/min per 1.73m².

A much smaller proportion of H2 blocker users developed chronic kidney disease or

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