Preconception aspirin increases live birth rates

However, it might increase live birth rates in women with a single recent loss, US researchers have found.

Preconception use of low-dose aspirin in women undergoing in vitro fertilisation (IVF) prompted the US researchers to investigate its use in women who had experienced recurrent pregnancy loss and were attempting to conceive again naturally. 

“Preconception use of low-dose aspirin improves endometrial growth and vascularisation in women undergoing in vitro fertilisation, thus preconception-initiated low-dose aspirin might positively affect downstream pregnancy outcomes during a crucial treatment window,” the authors suggested.

The study randomised just over 1000 women to receive aspirin at 81mg and folic acid or placebo and folic acid for six menstrual cycles while attempting to conceive, or until 36 weeks’ gestation for those who did become pregnant.

Overall, there was no significant difference in live birth