Prediabetes increases cancer risk: study

Researchers reviewed 16 studies that included nearly 900,000 people from around the world and found that people with prediabetes had a 15% overall increased risk of cancer.

The condition was significantly associated with increased risks of cancer of the stomach/colorectum (relative risk, RR 1.55), liver (RR 2.01), pancreas (RR 1.19), breast (RR 1.19) and endometrium (RR 1.60).

There was no link between prediabetes and lung, prostate, ovarian, kidney or bladder cancer.

According to the researchers, subgroup analyses showed no differences in cancer risk by sex, age or follow-up duration, but did reveal a significantly higher relative risk for Asian (1.50) than non-Asian patients (1.12).

In a sub-analysis that controlled for BMI, the presence of prediabetes and obesity was associated with a 22% increased risk of cancer.

Prediabetes was defined as impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both.