Pregabalin effective after knee replacement

Pregabalin is effective in reducing pain and opioid use following knee replacement surgery, new findings show.

Compared with placebo, pregabalin (Lyrica) decreased a visual pain scale at both 24 hours and 48 hours post operatively, at rest or mobilisation, a literature review shows.

It also lessened the amount of opioid analgesia used, without increasing nausea and vomiting in patients who