Preventing PPI harm in the elderly

Answer

The absolute risk from long-term use of PPIs is very low, but some older people may carry an elevated risk of harm from rare adverse events, including increased risk of fractures and greater susceptibility to enteric infections or community acquired pneumonia. 1-9

There is also a risk of reduced anti-platelet effect when PPIs are coadministered with clopidogrel. 10,11

PPIs

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