Probenecid lowers CVD risk in gout


Clare Pain

The elevated risk of cardiovascular disease (CVD) with gout might be lowered in elderly patients if they take probenecid rather than allopurinol, a large study suggests.

Patients taking probenecid had an incidence rate of hospitalisation for myocardial infarction (MI) or stroke of 2.36 per 100 person-years, compared with 2.83 for closely-matched patients on allopurinol, the researchers reported.

The large, observational cohort study compared cardiovascular events among 9722 American patients older than 65 with gout who were on probenecid with those among 29,166