Probenecid lowers CVD risk in gout


Clare Pain

The elevated risk of cardiovascular disease (CVD) with gout might be lowered in elderly patients if they take probenecid rather than allopurinol, a large study suggests.

Patients taking probenecid had an incidence rate of hospitalisation for myocardial infarction (MI) or stroke of 2.36 per 100 person-years, compared with 2.83 for closely-matched patients on allopurinol, the researchers reported.

The large, observational cohort study compared cardiovascular events among 9722 American patients older than 65 with gout who were on probenecid with those