Proof statins benefit women

Australian and international researchers have completed a meta-analysis of individual data from more than 174,000 trial participants, finding “conclusive” evidence that statins reduce cardiovascular disease (CVD) in women, including those who have never had a cardiovascular event.

The researchers looked at 22 trials of statins versus controls and five trials comparing more intensive versus less intensive statin therapy, which were a part of the Cholesterol Treatment Trialists’ Collaboration.

The team, led by Professor Anthony Keech, a professor of medicine, cardiology and epidemiology at the University of Sydney, found that statin therapy reduced the risk of a major vascular event (heart attack, stroke, bypass surgery, cardiac death) by 21% for each 1mmol/L reduction in LDL-cholesterol.

The study shows that statins also reduce all-cause mortality by 9% per 1mmol/L reduction in LDL-cholesterol — a finding never before shown in