Psychostimulants and ADHD

Using an animal model, they identified a network of nerve terminals where stimulation of dopamine D4 receptors depresses motor activity. “This network is localised deep in the brain, in the basal ganglia and the thalamus,” says lead researcher Professor David Erlij, “and its responses explain the reduction in motor activity caused by psychostimulants”.

Professor Erlij believes ADHD is caused by abnormalities of dopamine signalling in the brain, and that the dopamine D4 receptor gene is abnormal in these patients.

Neuropharmacology 2012; 62(2):1111-18