Researchers find distinctive signature in melancholic depression

Australian researchers have identified a distinctive brain signature in people with melancholic depression, supporting calls for its classification as a unique mood disorder.

Their findings published in Jama Psychiatry provide new information about the causes of depression, with senior author Professor Gordon Parker  arguing that melancholic depression is inadequately differentiated from other forms of clinical depression by current official diagnostic manuals.

The UNSW psychiatry professor says the condition has specific symptoms, including impaired