Routine calcium in pregnancy queried

Publication bias in small studies was “almost certainly” behind previous findings suggesting a benefit of supplementation for general prophylaxis, according to Alec Welsh, an author of the study and professor of maternal-fetal medicine at the University of NSW.

The analysis included 10 trials, with a total 25,000 women, comparing calcium supplementation in pregnancy to placebo.

While supplementation appeared to reduce the risk of pre-eclampsia in general (by 38%), the researchers from Sydney’s Royal Hospital for Women found that the effects were not statistically significant when smaller