Scientists shed light on therapy resistance

Up to 15% of the East Asian population is thought to carry the mutation making them resistant to tyrosine kinase inhibitor (TKI) therapy, and work is also underway on a targeted drug to overcome this.

“There may well be other, yet to be discovered gene variations that account for drug resistance in different world populations,” the authors said.

“These findings underscore the importance of learning all we can about cancer pathways, mutations, and treatments that work for different types of individuals.”

Nature Medicine 2012; online 18 Mar