Sequential chemo best in metastatic breast cancer

Combination chemotherapy does not provide a survival benefit to women with metastatic breast cancer compared with sequential therapy, an Australian-authored Cochrane review finds.

In fact, combination therapy carried a 16% higher risk of disease progression – a result that remained consistent across a number of subgroups, according to the analysis of 12 trials and over 2,300 patients.

Although there were higher overall tumour response rates with combination therapy there was significant heterogeneity