Slow allopurinol dose escalation effective in gout

It is safe to slowly escalate allopurinol levels beyond the creatinine-clearance-based dose in patients with gout, two year results from a New Zealand study have confirmed

In April Rheumatology Update reported on the unblinded 12 month clinical trial comparing remaining on a creatinine-clearance-based dose of the drug to gentle dose escalation to bring serum urate levels to <6mg/dL.

In a trial extension to determine safety and efficacy, the 93 participants in the control arm

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