'Spiral of decline': Australian researchers' polypharmacy warning

POLYPHARMACY can trigger a spiral of decline into frailty and death in older men, with each additional medication increasing mortality risk by 22%, an Australian cohort study has found.

In nearly 2000 men aged 70 or older, higher exposure to sedative and anticholinergic medications (measured using the Drug Burden Index) was linked with higher mortality transitions from a robust state, to various stages of frailty, and finally death.

Every unit increase in the Drug Burden Index was associated with a 2.75 times greater risk of mortality, as well as an increased risk of frailty among high