SSRIs no better than talking therapy

TALKING therapy may be as effective as SSRIs for treating major depression, according to a systematic review, but the authors caution that the evidence base is weak.

The meta-analysis of 11 randomised controlled trials comparing second-generation antidepressants to cognitive behavioural therapy (CBT) found no statistically significant difference in effectiveness for response, remission or change in depression score.

Similarly, no significant differences were found in rates of overall study discontinuation or discontinuation