Statin approved for primary CV prevention
THE first statin has been approved for primary cardiovascular prevention in Australia, despite controversy over clinical trial results underlying the indication.
AstraZeneca, maker of rosuvastatin (Crestor), announced last week the drug had received an indication for prevention of major cardiovascular events in men 50 years or older, and women 60 years or older, with no clinically evident CVD but with at least two conventional risk factors.
The new indication is based on the findings of the JUPITER (Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin) study in around 17,000 people, published in 2008. It showed that 20 mg of rosuvastatin daily reduced major cardiovascular events by 44% compared with placebo after nearly two years.
The trial was stopped early due to the benefit.
The results were widely criticised because the controversial high-sensitivity C-reactive protein