Stroke and low cholesterol link

The Chinese authors pooled data from 23 prospective studies of nearly 1.5 million participants and 8000 haemorrhagic strokes.

They found an increment of 1mmol/L in total cholesterol concentration was associated with a 15% decreased risk of stroke. Lower LDL cholesterol was also associated with a higher risk of haemorrhagic stroke.

The authors suggested low cholesterol may promote arterial medial layer smooth muscle cell necrosis with the impaired endothelium more susceptible to microaneurysms, or be a surrogate