Study links human papillomavirus to causal role in bladder cancer

MORE evidence has emerged implicating human papillomavirus (HPV) as an important cause of certain malignancies, with a Japanese study finding viral DNA in 15% of bladder cancers.

Researchers looked for genetic traces in 117 frozen tumour samples, with HPV DNA more likely to be detected within lower-grade tumours from patients aged under 60 years.
 “Analysis indicated that high-risk HPV DNA was localised in the nuclei of tumour cells of all HPV-positive samples,” the researchers said.

“The current results indicated that high-risk HPV is likely to be a causative agent of some low-grade bladder carcinomas that develop in younger patients.”

Cancer 2011; 117:2067-76