'Surprising result': Higher carbidopa dose may cut Parkinson's off-time

Exploratory study suggests the 4:1 levodopa-carbidopa ratio may not be optimal

A higher dose of carbidopa, in combination with usual doses of levodopa and entacapone, can reduce ‘off-time’ in patients with fluctuating Parkinson's disease, compared with standard levodopa/carbidopa combinations, according to results from an early clinical trial.