Testosterone therapy ups MI risk: study

The same risk was also observed in men younger than 65 with a history of heart disease, while no additional risk was observed in younger men without a history of heart attack. The researchers say the study is the first to investigate the effect of TT on myocardial infarction (MI) in men under 65.

The cohort study looked at the medical records of over 55,500 men who had been prescribed testosterone therapy, including more than 48,000 under 65, and examined risk of heart attack in all subjects over the first 90 days of treatment. 

When they continued to follow the men for another 90 days, the risk declined to baseline in men who did not fill their prescription.

“The pattern of change in risk by supply of testosterone is consistent with an effect of the drug,” the authors reported.

While the study was not powered to establish a cause-and-effect relationship between TT and increased risk of heart attack, the researchers