Top 5 clinical stories of 2015

1. BP targets challenged

AUSTRALIAN clinicians early this year challenged the wisdom of European and US guidelines relaxing blood pressure targets to make 140mmHg the trigger for antihypertensives. Their comments followed a Swedish meta-analysis showing patients with diabetes who achieved a systolic BP of 130mmHg had about a 25% lower stroke risk. Evidence for a benefit of low targets continued to roll in, including from the halted SPRINT study (also here) so that by November speculation was mounting that updated Australian guidelines due soon were