Understanding long-term PPI therapy

Long-term use of PPIs is only recommended in people:

  • with gastro-oesophageal reflux disease (GORD) who have frequent, significantly troublesome symptoms not adequately controlled with step-down therapy;
  • with severe oesophagitis, oesophageal stricture, oesophageal scleroderma or Zollinger-Ellison syndrome;
  • with H. pylori-related peptic ulcer disease where eradication therapy fails or is contraindicated; or
  • on long-term NSAIDs.1,2

Undertake regular reviews of people on both short- and long-term PPI therapy, and if

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