Viral infection link to Sjogren’s syndrome
Australian researchers have discovered a cause for the development of Sjogren’s syndrome (SS), paving the way for better targeted treatments.
A mouse model study led by Professor Mariape Degli-Esposti (pictured) from the University of Western Australia found chronic murine cytomegalovirus (MCMV) can trigger SS.
This is caused by the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) on natural killer (NK) cells eliminating CD4+ T cells in the salivary gland during the viral infection.
The elimination limits antiviral responses to the development of autoimmunity, giving rise to