Vitamin D and death

Severe vitamin D deficiency independently predicts all-cause mortality in patients with type 1 diabetes, but it doesn’t predict development of microvascular complications in eyes or kidneys. 

Those were the key findings of a prospective observational study of 227 newly diagnosed patients in Denmark who were followed for a median of 26 years. 

Patients with vitamin D levels in the lowest 10% (less than 15.5 nmol/L) were considered severely vitamin D deficient. In total, 22 patients fell into that category, and 32% of that group died during the follow-up (seven patients). By contrast, 19% of patients with vitamin D levels above 15.5 nmol/L died in the same period. 

The association with all-cause mortality occurred independently of glycaemic control, urinary albumin excretion rate and conventional cardiovascular risk factors. Thirty-seven per cent of the patients developed microalbuminuria, with 12% eventually developing