Warning over topiramate in pregnancy

PREGNANT women taking topiramate in combination with other antiepileptics run a much higher risk of fetal malformations, Australian neurologists warn.

Their 15-year study looked at more than 1800 pregnancies exposed to antiepileptic drugs (AEDs), used as monotherapy or in combination, focusing on levetiracetam and topiramate. 

Nearly 15% of pregnancies involving topiramate as part of AED polytherapy resulted in fetal malformations, compared with 7% of those without topiramate.  

Risk of malformations was not higher with levetiracetam, or with topiramate