From wart to invasive malignancy

This was an invasive squamous cell carcinoma arising within an SCC in situ. This is a wart-induced cancer, but an oncogenic papillomavirus caused it.

Most genital warts are due to types 6 and 11, and these are not oncogenic. However, other serotypes are.

The malignant changes are often slow to develop, but when invasive, this tumour can spread to regional lymph glands. This one was removed surgically with preservation of the glans.

The patient had previously presented with a lesion at the site that was biopsied and reported as SCC in situ but,