Weight and activity aggravate bone marrow lesions

Most bone marrow lesions (BMLs) remain stable for at least 10 years, but strenuous activity and higher body mass index are likely to lead to increased size, according to an Australian study.

And bigger lesions are associated with increased pain, particularly for males with a family history of osteoarthritis (OA), write the researchers, who assessed adult subjects at two years and ten years.

Of the 198 participants, 109 were offspring of a parent with a knee replacement and 89 were community-based controls.