Weight gain impact on prostate cancer
Using data from a study of more than 17,000 men, the researchers showed that those who gained weight between the age of 18 years and entering the study between 40 and 69 years of age had a higher risk of more aggressive prostate cancer and death.
The risk of death from prostate cancer increased by 13% for every 5 kg of weight put on, and men who gained 20 kg or more in adulthood had nearly double the risk (84% increased risk).
Studies looking for associations between BMI and prostate cancer have produced inconsistent results, but a link makes sense as excess body fat is associated with conditions that might contribute to aggressive disease such as hormone imbalance, insulin resistance and inflammation.
In addition, prostate cancer detection may be delayed in obese men due to lower circulating concentrations of testosterone and PSA and this could explain the higher risk of fatal cancer in men with high weight gain compared to the risk of non