What contributes to osteoporosis in RA?

Patients with rheumatoid arthritis (RA) and high levels of anti-cyclic citrullinated peptide (anti-CCP) are more likely to have low bone mineral density (BMD), while increased limb muscle mass is protective, a US study reveals

In a cohort of 138 patients with RA, more than half (52%) had low femoral neck BMD, with age and high anti-CPP positivity being correlated with reduced BMD, the authors reported in Arthritis Care and Research.

And for those patients with high anti-CPP (more than three times the upper limit of normal), there was a linear relationship, with more positive serology