When more is not better: ACCORD trial

It followed a cohort of 4687 patients with hypertension and diabetes for an average of 4.7 years.

Intensive treatment involved reducing the patients’ systolic BP from 130–180mmHg to <120mmHg. This turned out to be no more effective at preventing cardiovascular (CV) deaths than reducing the systolic pressure to <140mmHg. The researchers hypothesised central obesity could have influenced the results, so results were analysed to consider factors such as waist-to-height ratio.

In this analysis, the patients had a mean BMI of 32kg/m2. Their mean