Which anticholinergics are worst for cognition?

One drug class may be problematic

Different classes of anticholinergic drugs have differing effects on cognitive function, with antipsychotics possibly being the most detrimental, a French study suggests.

The cross-sectional study of more than 34,000 people aged 45-70 years examined how performance on a battery of cognitive tests was related to receiving scripts for anticholinergic medications of any type in the preceding three years.

While it was already known that anticholinergics are associated with poorer cognition in elderly patients, this study, which used patients from the large CONSTANCES cohort