A Canadian doctor has shared the case of a patient who developed severe electrolyte imbalance after being continuously prescribed the drugs.
The 65-year-old patient's nocturnal shouting and dream enactment began when she started high dose omeprazole, her UK doctors say.
After three days of omeprazole the 38-year-old couldn’t get an erection, but he returned to normal after stopping the PPI
There appears to be a small reduction in HbA1c, but longer-term studies are needed, commentators say.
The study suggests risk rises with longer-term use, the researchers say.
Although hyponatraemia-associated with the drugs is rare, it still needs to be recognised in practice, say Dutch researchers.
Dose could be adjusted according to liver enzyme activity, expert suggests.
But careful patient selection is required, say researchers.
Trial compares a PPI with an H2-receptor antagonist for Helicobacter pylori-negative ulcers.
Patients who have taken acid inhibitors are twice as likely to need antiallergics.