Avatars take lead role in future CF therapy

Organoid ‘avatars’ are among the technological advances for treating cystic fibrosis

Under the bright lights of a lab, a cluster of human cells inside a dish is exposed to a novel — and expensive — drug to test its efficacy.

Still from Avatar movie

These organoids act like avatars, boldly going where it’s unsafe for real humans to go. Welcome to the frontiers of research into treating cystic fibrosis (CF).

History of CF

The treatment of this condition has changed considerably in recent times. In the past, the mainstay was reactive management, and involved treating complications and lung disease once they arose.