Glucosamine, chondroitin for knee OA

An Australian population study of 266,848 participants aged 45 or older demonstrated that glucosamine is widely used for OA (22% of participants, particularly females).3

A recent multicentre randomised controlled trial (RCT) of 606 patients with moderate-to-severe knee pain from 42 centres in Europe demonstrated that combined chondroitin sulfate (CS) 400mg and glucosamine hydrochloride (GH) 500mg three times a day or celecoxib 200mg every day for six months had similar significant pain reduction.

The supplement had “comparable efficacy to celecoxib in

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