The infiltration of tissues by mast cells can lead not only to skin lesions, but also generalised flushing and tachycardia

Mastocytosis is a general term referring to a group of conditions with clinical features caused by mast cell infiltration of tissues and the release of chemical mediators, including histamine, prostaglandin D2, heparin, proteases, leukotrienes and chemotactic factors from these cells.