The latest on diagnosing and managing pemphigus, a rare autoimmune bullous disease that results in the formation of intraepidermal blisters.
Pemphigus is a rare autoimmune bullous disease that affects the skin and mucous membranes, resulting in the formation of intraepidermal blisters.
The condition is caused by autoantibodies that attack desmogleins, which are principal components of desmosomes that attach adjacent epidermal cells to each other.
The autoantibodies result in the loss of these intercellular connections, a process called acantholysis.
There are many subtypes of pemphigus, which are detailed below.
This is the most common subtype of pemphigus.
The incidence of pemphigus vulgaris is reported to be 0.42-1.62 cases per 100,000 people and accounts for 80% of all