‘Block and replace’ has little benefit in Graves’ disease

A new study has found little evidence to back anecdotal claims that “block and replace” regimens confer any advantage over titration of antithyroid drugs in patients with Graves disease.

Patients who used a block and replace regimen (of a high dose of antithyriod drug combined with levothyroxine) were no less prone to fluctuating thyroid function than those who had their drugs titrated on the basis of  thyroid function tests, a

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