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An unexpected local effect of a GLP-1 RA

A patient’s initial GLP-1 injection-site reactions evolve into subcutaneous fat necrosis, resulting in persistent localised tissue loss and visible deformity

This article has been allocated 0.5 EA by the RACGP and ACRRM for the 2026-2028 triennium.

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Joanne is a 53-year-old sales assistant who presents with visible depressions (‘divots’) in the right lateral thigh and the left lower abdomen.

The right lateral thigh lesions developed first, followed by the abdominal depressions.

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