What's the evidence for metformin in the absence of diabetes?
A 25-year-old man with bipolar affective disorder saw me recently.
His symptoms were well controlled with quetiapine (Seroquel), but I noticed his psychiatrist had prescribed metformin. The patient had neither diabetes nor pre-diabetes.
I wondered about the evidence that supported this practice.
What is the effect of metformin on cardiovascular disease (CVD) in people without diabetes on long-term antipsychotic medication?
The research evidence
Step 1: The