Medical Must-See: How a bright yellow ulcer sparked a three-way ‘diagnostic dispute’

A skin biopsy was 'essential' for uncovering the culprit, say doctors.
Rachel Fieldhouse

A young man’s yellow leg ulcer has served as a lesson in considering differential and albeit unusual diagnoses after US dermatologists discovered it was caused by sickle cell disease.

The 21-year-old patient presented to ED at the Baylor University Medical Center in Houston, Texas, with a “rapidly progressive, exquisitely painful ulcer” with yellow slough on his right leg.