When a man presented to an Italian endocrinology clinic with this brainy-looking scalp, it turned out to be a sign of a much ‘larger’ problem.

The 37-year-old’s wife was the first to notice the increasing skin folds, with the patient also reporting a four-year history of excessive sweating, headaches and joint pain.

Examination revealed a thickening of the scalp skin with ridges and furrows, as well as enlarged hands and feet, and a protruding lower jaw (hint: this is the 007 connection).