Watch this man's pulsating pupils move in sync with his heart

Beating is in the eye of the beholder

Doctors in Mexico didn’t miss a beat when it came to diagnosing this patient’s pulsating pupils.

The 73-year-old man with a history of hypertension initially presented to an ED complaining of shortness of breath.

Doctors noted a high blood pressure, and heart and respiratory rate, as well as a crescendo–decrescendo systolic murmur and a decrescendo diastolic murmur. But it was the ophthalmic examination that revealed a truly unusual sight.

Captured on video, the patient’s pupils could be seen contracting and dilating in time with his heartbeat.

“Known as Landolfi’s sign, this finding may be seen in patients with severe aortic regurgitation and is a manifestation of wide pulse pressure and large stroke volume in the iridial vessels, which causes systolic constriction and diastolic dilation of the pupils,” the cardiologists explained in the New England Journal of Medicine.